Lygos’ novel manufacturing technology decreases CO2 emissions, eliminates toxic inputs and could replace the existing petroleum production process for malonic acid at lower cost and less energy.
Malonic acid is currently a high-value specialty chemical useful for production of a variety of pharmaceuticals, flavors, fragrances, and specialty materials. The petrochemical process to produce malonic acid requires chloroacetic acid and sodium cyanide, and is both costly and environmentally hazardous. Lygos’ fermentation technology is environmentally benign, scalable, and enables production of malonic acid at a lower cost than the current petrochemical manufacturing process.
A versatile compound, malonic acid was identified by the U.S. Department of Energy as one of the “Top 30 Value Added Chemicals” to be produced from biomass-derived sugar, instead of petroleum. Lygos has identified over $1 billion in derivative specialty and commodity chemicals that can be accessed from malonic acid, and developing its fermentation technology is key to enabling these opportunities.
“This is an exciting achievement for our team – it’s the first time malonic acid has been produced in meaningful quantities from renewable materials instead of petroleum,” said Dr. Eric Steen, CEO of Lygos. “The process metrics we observed at lab scale were successfully transitioned to pilot scale. With this manufacturing run, we are able to provide samples of high quality malonic acid to customers and partners. As we move forward with commercialization, we’re seeking additional partners to accelerate larger scale manufacturing and unlock new product applications.” The scale-up was performed at the Advanced Biofuels Process Demonstration Unit (ABPDU) at Lawrence Berkeley National Laboratory (www.abpdu.lbl.gov).
“Lygos’ process transfer went smoothly and proved to be robust. We look forward to further scale-up activities with our partner,” said Todd Pray, head of ABPDU.
The successful achievement of pilot scale manufacturing was completed in the research phase of a program funded in part by the Bioenergy Technologies Office, in the U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy (EERE) (www.energy.gov/eere/bioenergy).