As for the host that produces fibroin, it is most cost effective to use microorganisms. Still, it has been impossible to achieve a high enough production efficiency. Even with the microorganism that offers the highest production efficiency, it costs hundred millions or billions of yen to ensure an enough amount of the microorganism for a large-scale experiment.
To improve production efficiency, Spiber made improvements to the sequences of spider silk’s molecules and genes. The company designed new genes, actually synthesized them and repeated fermentative production tests using microorganisms. Based on the data obtained from the tests, it tested hypotheses and kept giving feedback to the next-generation molecular design to increase productivity.
Tags: sixth-generation gene, optimizing, safety, fiber spinning process, protein, HFIP, HFA, toxic, patents
Source: Tech On, 2013-05-30.